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Structure of the polypeptide chain Alpha carbon atom Primary structure: the protein sequence 20 amino acids with different characteristics: small, large, polar, lipophilic, charged,… Structure of the polypeptide chain Space-filling model of the same Colors: Carbon=light grey Nitrogen=blue Oxygen=red Sulfur=yellow 1B6Q JMOLīasics of protein structure Primary structure Secondary structure Tertiary structure Quaternary structure Nota bene: some proteins are inherently disordered Structure of the polypeptide chain Another view of the same 1B6Q JMOL cartoon Structure of the polypeptide chain Convenient, but real molecules fill up space Colors: Carbon=light grey Nitrogen=blue Oxygen=red Sulfur=yellow 1B6Q Visualization with DeepView Experimental evidence for transmembrane domains.Posttranslational modifications: disulfide bonds, N-glycosylation,….Interactions with small ligands: metal ions, nucleotides, substrates, cofactors and inhibitors.

Prediction of function for uncharacterized proteins.Protein 3D-structure analysis why and howģD-structures are precious sources of information

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